Translations:Somatyczne komórki macierzyste/1/en

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Definition

Somatic stem cells are undifferentiated cells that reside in many tissues of the adult body, where they play an important role in maintaining homeostasisand damaged tissues repair. They have a capacity for self-renewal and differentiation. Populations of somatic stem cells residing in a specific microenvironment of their cellular niche, are heterogenous and dynamic, and consisting of both active and quiescent cells. Somatic stem cells are an attractive tool for regenerative medicine, as compared to some types of immortalized or induced pluripotent cell lines, they do not carry a risk of tumor formation, do not come from embryos, and show low immunogenicity even in allogeneic systems [1] [2] [3].

  1. ↑ da Silva Meirelles L, Chagastelles PC, Nardi NB. Mesenchymal stem cells reside in virtually all post-natal organs and tissues. J Cell Sci. 2006 Jun 1;119(Pt 11):2204-13. doi: 10.1242/jcs.02932. Epub 2006 May 9
  2. ↑ Nombela-Arrieta C, Ritz J, Silberstein LE. The elusive nature and function of mesenchymal stem cells. Nat Rev Mol Cell Biol. 2011 Feb;12(2):126-31. doi: 10.1038/nrm3049
  3. ↑ Klimczak A, Kozlowska U. Mesenchymal Stromal Cells and Tissue-Specific Progenitor Cells: Their Role in Tissue Homeostasis. Stem Cells Int. 2016;2016:4285215. doi: 10.1155/2016/4285215. Epub 2015 Dec 28
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