Translations:Mezenchymalne komórki macierzyste/1/en: Różnice pomiędzy wersjami

Z BINWIT
Przejdź do nawigacji Przejdź do wyszukiwania
 
Linia 3: Linia 3:
Mesenchymal stem / stromal cells have attracted special attention from the scientific world since their first isolation from the bone marrow by Friedenstein in the 1960s and have been described as adherent cells (adherent to the surface of plastic culture dishes) with a fibroblast-like morphology <ref>Friedenstein AJ, Petrakova KV, Kurolesova AI, Frolova GP. Heterotopic of bone marrow. Analysis of precursor cells for osteogenic and hematopoietic tissues. Transplantation 1968; 6: 230-47</ref> <ref>Friedenstein A, Kuralesova AI. Osteogenic precursor cells of bone marrow in radiation chimeras. Transplantation 1971; 12: 99-108</ref>. However, the term mesenchymal stem cells was proposed by Caplan and introduced to denote a type of cells that originated from adult bone marrow with a natural capacity for multipotential differentiation into diverse types of cells of mesenchymal origin <ref>Caplan AI. Mesenchymal stem cells. J Orthop Res 1991; 9: 641-50</ref>.
Mesenchymal stem / stromal cells have attracted special attention from the scientific world since their first isolation from the bone marrow by Friedenstein in the 1960s and have been described as adherent cells (adherent to the surface of plastic culture dishes) with a fibroblast-like morphology <ref>Friedenstein AJ, Petrakova KV, Kurolesova AI, Frolova GP. Heterotopic of bone marrow. Analysis of precursor cells for osteogenic and hematopoietic tissues. Transplantation 1968; 6: 230-47</ref> <ref>Friedenstein A, Kuralesova AI. Osteogenic precursor cells of bone marrow in radiation chimeras. Transplantation 1971; 12: 99-108</ref>. However, the term mesenchymal stem cells was proposed by Caplan and introduced to denote a type of cells that originated from adult bone marrow with a natural capacity for multipotential differentiation into diverse types of cells of mesenchymal origin <ref>Caplan AI. Mesenchymal stem cells. J Orthop Res 1991; 9: 641-50</ref>.
MSC cells are a heterogeneous population characterized by specific properties, i.e. the ability to self-renewal, the ability to differentiation into progenitor cells of a specific cell line involved in the regeneration of the damaged tissue in which they reside, and multipotency, i.e. the ability to differentiate into different types cells not only of mesodermal origin. Various types of tissue resident MSCs have been described in the literature and many reports indicate their biological features make these cells specific for the regeneration of the tissue from which they originate, however, their heterogeneity allows them to differentiate into different cell types <ref>Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, Moorman MA, Simonetti DW, Craig S, Marshak DR. Multilineage potential of adult human mesenchymal stem cells. Science. 1999 Apr 2;284(5411):143-7. doi: 10.1126/science.284.5411.143</ref>. Cells bearing the characteristics of MSCs have been isolated from many organs and tissues of the human body, including bone marrow, adipose tissue, skin, skeletal muscle, tendons, bones, liver, kidney, lung, spleen, pancreas, thymus, dental pulp, synovium and umbilical cords <ref>da Silva Meirelles L, Chagastelles PC, Nardi NB. Mesenchymal stem cells reside in virtually all post-natal organs and tissues. J Cell Sci. 2006 Jun 1;119(Pt 11):2204-13. doi: 10.1242/jcs.02932. Epub 2006 May 9</ref> <ref>Klimczak A, Kozlowska U. Mesenchymal Stromal Cells and Tissue-Specific Progenitor Cells: Their Role in Tissue Homeostasis. Stem Cells Int. 2016;2016:4285215. doi: 10.1155/2016/4285215. Epub 2015 Dec 28</ref> <ref>Kozlowska U, Krawczenko A, Futoma K, Jurek T, Rorat M, Patrzalek D, Klimczak A. Similarities and differences between mesenchymal stem/progenitor cells derived from various human tissues. World J Stem Cells. 2019 Jun 26;11(6):347-374. doi: 10.4252/wjsc.v11.i6.347</ref>.
MSC cells are a heterogeneous population characterized by specific properties, i.e. the ability to self-renewal, the ability to differentiation into progenitor cells of a specific cell line involved in the regeneration of the damaged tissue in which they reside, and multipotency, i.e. the ability to differentiate into different types cells not only of mesodermal origin. Various types of tissue resident MSCs have been described in the literature and many reports indicate their biological features make these cells specific for the regeneration of the tissue from which they originate, however, their heterogeneity allows them to differentiate into different cell types <ref>Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, Moorman MA, Simonetti DW, Craig S, Marshak DR. Multilineage potential of adult human mesenchymal stem cells. Science. 1999 Apr 2;284(5411):143-7. doi: 10.1126/science.284.5411.143</ref>. Cells bearing the characteristics of MSCs have been isolated from many organs and tissues of the human body, including bone marrow, adipose tissue, skin, skeletal muscle, tendons, bones, liver, kidney, lung, spleen, pancreas, thymus, dental pulp, synovium and umbilical cords <ref>da Silva Meirelles L, Chagastelles PC, Nardi NB. Mesenchymal stem cells reside in virtually all post-natal organs and tissues. J Cell Sci. 2006 Jun 1;119(Pt 11):2204-13. doi: 10.1242/jcs.02932. Epub 2006 May 9</ref> <ref>Klimczak A, Kozlowska U. Mesenchymal Stromal Cells and Tissue-Specific Progenitor Cells: Their Role in Tissue Homeostasis. Stem Cells Int. 2016;2016:4285215. doi: 10.1155/2016/4285215. Epub 2015 Dec 28</ref> <ref>Kozlowska U, Krawczenko A, Futoma K, Jurek T, Rorat M, Patrzalek D, Klimczak A. Similarities and differences between mesenchymal stem/progenitor cells derived from various human tissues. World J Stem Cells. 2019 Jun 26;11(6):347-374. doi: 10.4252/wjsc.v11.i6.347</ref>.
There are no specific markers to identify MSCs, however, irrespective of their tissue origin, MSCs isolated from various tissues are characterized as non-hematopoietic cells that can be identified by the presence of many common markers, including the CD29, CD44, CD73, CD90, CD105 and MHC class I antigens. MSCs do not express hematopoietic and endothelial markers on their surface, e.g. CD14, CD31, CD34, CD45, and lack of expression of MHC class II antigens and co-stimulatory molecules CD40, CD80 and CD86, permitted their non-immunogenic properties. These biological features make MSCs isolated from adult tissues a promising source of cells for developing new therapeutic strategies in regenerative medicine <ref>Klimczak A, Kozlowska U, Kurpisz M. Muscle Stem/Progenitor Cells and Mesenchymal Stem Cells of Bone Marrow Origin for Skeletal Muscle Regeneration in Muscular Dystrophies. Arch Immunol Ther Exp (Warsz). 2018 Oct;66(5):341-354. doi: 10.1007/s00005-018-0509-7. Epub 2018 Mar 13</ref> <ref>Pittenger MF, Discher DE, Péault BM, Phinney DG, Hare JM, Caplan AI. Mesenchymal stem cell perspective: cell biology to clinical progress. NPJ Regen Med. 2019 Dec 2;4:22. doi: 10.1038/s41536-019-0083-6</ref> <ref>Murphy MB, Moncivais K, Caplan AI. Mesenchymal stem cells: environmentally responsive therapeutics for regenerative medicine. Exp Mol Med. 2013 Nov 15;45(11):e54. doi: 10.1038/emm.2013.94</ref> <ref>Rodríguez-Fuentes DE, Fernández-Garza LE, Samia-Meza JA, Barrera-Barrera SA, Caplan AI, Barrera-Saldaña HA. Mesenchymal Stem Cells Current Clinical Applications: A Systematic Review. Arch Med Res. 2021 Jan;52(1):93-101. doi: 10.1016/j.arcmed.2020.08.006. Epub 2020 Sep 22</ref>.
There are no specific markers to identify MSCs, however, irrespective of their tissue origin, MSCs isolated from various tissues are characterized as non-hematopoietic cells that can be identified by the presence of many common markers, including the CD29, CD44, CD73, CD90, CD105 and MHC class I antigens. MSCs do not express hematopoietic and endothelial markers on their surface, e.g. CD14, CD31, CD34, CD45, and lack of expression of MHC class II antigens and co-stimulatory molecules CD40, CD80 and CD86, permitted their non-immunogenic properties. These biological features make MSCs isolated from adult tissues a promising source of cells for developing new therapeutic strategies in regenerative medicine <ref>Pittenger MF, Discher DE, Péault BM, Phinney DG, Hare JM, Caplan AI. Mesenchymal stem cell perspective: cell biology to clinical progress. NPJ Regen Med. 2019 Dec 2;4:22. doi: 10.1038/s41536-019-0083-6</ref> <ref>Murphy MB, Moncivais K, Caplan AI. Mesenchymal stem cells: environmentally responsive therapeutics for regenerative medicine. Exp Mol Med. 2013 Nov 15;45(11):e54. doi: 10.1038/emm.2013.94</ref> <ref>Rodríguez-Fuentes DE, Fernández-Garza LE, Samia-Meza JA, Barrera-Barrera SA, Caplan AI, Barrera-Saldaña HA. Mesenchymal Stem Cells Current Clinical Applications: A Systematic Review. Arch Med Res. 2021 Jan;52(1):93-101. doi: 10.1016/j.arcmed.2020.08.006. Epub 2020 Sep 22</ref>.

Aktualna wersja na dzień 08:42, 25 cze 2021

Objaśnienie komunikatu (zmień)
Ten komunikat nie posiada dokumentacji. Jeśli wiesz gdzie lub jak ten komunikat jest używany, możesz pomóc innym tłumaczom przez dodanie dokumentacji do tego komunikatu.
Tekst źródłowy komunikatu (Mezenchymalne komórki macierzyste)
=Definicja=
Mezenchymalne komórki macierzyste, zwane również komórkami zrębowymi (ang. mesenchymal stem /stromal cells - MSC) to multipotencjalne komórki pochodzenia mezodermalnego, rezydujące w wielu tkankach dorosłego organizmu, zdolne od samoodnowy i różnicowania zarówno do komórek tkanki, z której się wywodzą jak i do innych komórek pochodzenia mezenchymalnego i niemezenchymalnego .
Mezenchymalne komórki macierzyste / zrębowe skupiły szczególną uwagę świata nauki od czasu ich pierwszej izolacji ze szpiku kostnego przez Friedensteina w latach sześćdziesiątych XX wieku i zostały opisane jako komórki adherentne (przylegające do powierzchni naczyń hodowlanych) o morfologii podobnej do fibroblastów <ref>Friedenstein AJ, Petrakova KV, Kurolesova AI, Frolova GP. Heterotopic of bone marrow. Analysis of precursor cells for osteogenic and hematopoietic tissues. Transplantation 1968; 6: 230-47.</ref> <ref>Friedenstein A, Kuralesova AI. Osteogenic precursor cells of bone marrow in radiation chimeras. Transplantation 1971; 12: 99-108.</ref>. Jednak termin mezenchymalne komórki macierzyste został zaproponowany przez Caplana i wprowadzony w celu określenia rodzaju komórek pochodzących ze szpiku kostnego z naturalną zdolnością do multipotencjalnego różnicowania się w różne typy komórek pochodzenia mezenchymalnego <ref>Caplan AI. Mesenchymal stem cells. J Orthop Res 1991; 9: 641-50.</ref>.
Komórki MSC to heterogenna populacja charakteryzująca się specyficznymi właściwościami tj.: zdolnością do samoodnawiania,  zdolnością do zapoczątkowania potomnych komórek progenitorowych ukierunkowanych na różnicowanie w określoną linię komórkową biorącą udział w regeneracji uszkodzonej tkanki, w której rezydują, oraz multipotencją  czyli zdolnością do różnicowania się w różne typy komórek nie tylko pochodzenia mezodermalnego. W literaturze opisano różne rodzaje MSC rezydujących w tkankach i wiele doniesień wskazuje na ich biologiczne cechy, która sprawiają, że komórki te  są specyficzne dla regeneracji tkanki, z której pochodzą, a ich heterogenność pozwala im różnicować się w różne typy komórek <ref>Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, Moorman MA, Simonetti DW, Craig S, Marshak DR. Multilineage potential of adult human mesenchymal stem cells. Science. 1999 Apr 2;284(5411):143-7. doi: 10.1126/science.284.5411.143.</ref>. Komórki posiadające cechy MSC zostały wyizolowane z wielu narządów i tkanek ludzkiego organizmu, w tym ze szpiku kostnego, tkanki tłuszczowej, skóry, mięśni szkieletowych, ścięgien, kości, wątroby, nerek, płuc, śledziony, trzustki, grasicy, miazgi zębowej, błony maziowej i pępowiny <ref>da Silva Meirelles L, Chagastelles PC, Nardi NB. Mesenchymal stem cells reside in virtually all post-natal organs and tissues. J Cell Sci. 2006 Jun 1;119(Pt 11):2204-13. doi: 10.1242/jcs.02932. Epub 2006 May 9. </ref> <ref>Klimczak A, Kozlowska U. Mesenchymal Stromal Cells and Tissue-Specific Progenitor Cells: Their Role in Tissue Homeostasis. Stem Cells Int. 2016;2016:4285215. doi: 10.1155/2016/4285215. Epub 2015 Dec 28.</ref> <ref>Kozlowska U, Krawczenko A, Futoma K, Jurek T, Rorat M, Patrzalek D, Klimczak A. Similarities and differences between mesenchymal stem/progenitor cells derived from various human tissues. World J Stem Cells. 2019 Jun 26;11(6):347-374. doi: 10.4252/wjsc.v11.i6.347.</ref>.
Nie ma specyficznych markerów identyfikujących MSC, jednakże, niezależnie od pochodzenia tkankowego, MSC wyizolowane z różnych tkanek są charakteryzowane jako komórki niehematopoetyczne, które mogą być identyfikowane poprzez obecność wielu wspólnych markerów, w tym antygeny CD29, CD44, CD73, CD90, CD105 i MHC klasy I. MSC nie mają na swojej powierzchni  markerów hematopoetycznych i endotelialnych np. CD14, CD31, CD34, CD45, brak ekspresji antygenów MHC klasy II oraz brak cząsteczek kostymulujących CD40, CD80 i CD86, co warunkuje ich ograniczoną immunogenność.  Te cechy biologiczne sprawiają, że MSC izolowane z tkanek dorosłego organizmu są obiecującym źródłem komórek do opracowania nowych strategii terapeutycznych w medycynie regeneracyjnej <ref>Pittenger MF, Discher DE, Péault BM, Phinney DG, Hare JM, Caplan AI. Mesenchymal stem cell perspective: cell biology to clinical progress. NPJ Regen Med. 2019 Dec 2;4:22. doi: 10.1038/s41536-019-0083-6.</ref> <ref>Murphy MB, Moncivais K, Caplan AI. Mesenchymal stem cells: environmentally responsive therapeutics for regenerative medicine. Exp Mol Med. 2013 Nov 15;45(11):e54. doi: 10.1038/emm.2013.94.</ref> <ref>Rodríguez-Fuentes DE, Fernández-Garza LE, Samia-Meza JA, Barrera-Barrera SA, Caplan AI, Barrera-Saldaña HA. Mesenchymal Stem Cells Current Clinical Applications: A Systematic Review. Arch Med Res. 2021 Jan;52(1):93-101. doi: 10.1016/j.arcmed.2020.08.006. Epub 2020 Sep 22.</ref>.

Definition

Mesenchymal stem cells, also known as mesenchymal stromal cells (MSCs), are multipotent cells of mesodermal origin, residing in many tissues of the adult organism, capable of self-renewal and differentiation both into the cells of the tissue from which they originate and into other cells of mesenchymal and non-mesenchymal origin. Mesenchymal stem / stromal cells have attracted special attention from the scientific world since their first isolation from the bone marrow by Friedenstein in the 1960s and have been described as adherent cells (adherent to the surface of plastic culture dishes) with a fibroblast-like morphology [1] [2]. However, the term mesenchymal stem cells was proposed by Caplan and introduced to denote a type of cells that originated from adult bone marrow with a natural capacity for multipotential differentiation into diverse types of cells of mesenchymal origin [3]. MSC cells are a heterogeneous population characterized by specific properties, i.e. the ability to self-renewal, the ability to differentiation into progenitor cells of a specific cell line involved in the regeneration of the damaged tissue in which they reside, and multipotency, i.e. the ability to differentiate into different types cells not only of mesodermal origin. Various types of tissue resident MSCs have been described in the literature and many reports indicate their biological features make these cells specific for the regeneration of the tissue from which they originate, however, their heterogeneity allows them to differentiate into different cell types [4]. Cells bearing the characteristics of MSCs have been isolated from many organs and tissues of the human body, including bone marrow, adipose tissue, skin, skeletal muscle, tendons, bones, liver, kidney, lung, spleen, pancreas, thymus, dental pulp, synovium and umbilical cords [5] [6] [7]. There are no specific markers to identify MSCs, however, irrespective of their tissue origin, MSCs isolated from various tissues are characterized as non-hematopoietic cells that can be identified by the presence of many common markers, including the CD29, CD44, CD73, CD90, CD105 and MHC class I antigens. MSCs do not express hematopoietic and endothelial markers on their surface, e.g. CD14, CD31, CD34, CD45, and lack of expression of MHC class II antigens and co-stimulatory molecules CD40, CD80 and CD86, permitted their non-immunogenic properties. These biological features make MSCs isolated from adult tissues a promising source of cells for developing new therapeutic strategies in regenerative medicine [8] [9] [10].

  1. ↑ Friedenstein AJ, Petrakova KV, Kurolesova AI, Frolova GP. Heterotopic of bone marrow. Analysis of precursor cells for osteogenic and hematopoietic tissues. Transplantation 1968; 6: 230-47
  2. ↑ Friedenstein A, Kuralesova AI. Osteogenic precursor cells of bone marrow in radiation chimeras. Transplantation 1971; 12: 99-108
  3. ↑ Caplan AI. Mesenchymal stem cells. J Orthop Res 1991; 9: 641-50
  4. ↑ Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, Moorman MA, Simonetti DW, Craig S, Marshak DR. Multilineage potential of adult human mesenchymal stem cells. Science. 1999 Apr 2;284(5411):143-7. doi: 10.1126/science.284.5411.143
  5. ↑ da Silva Meirelles L, Chagastelles PC, Nardi NB. Mesenchymal stem cells reside in virtually all post-natal organs and tissues. J Cell Sci. 2006 Jun 1;119(Pt 11):2204-13. doi: 10.1242/jcs.02932. Epub 2006 May 9
  6. ↑ Klimczak A, Kozlowska U. Mesenchymal Stromal Cells and Tissue-Specific Progenitor Cells: Their Role in Tissue Homeostasis. Stem Cells Int. 2016;2016:4285215. doi: 10.1155/2016/4285215. Epub 2015 Dec 28
  7. ↑ Kozlowska U, Krawczenko A, Futoma K, Jurek T, Rorat M, Patrzalek D, Klimczak A. Similarities and differences between mesenchymal stem/progenitor cells derived from various human tissues. World J Stem Cells. 2019 Jun 26;11(6):347-374. doi: 10.4252/wjsc.v11.i6.347
  8. ↑ Pittenger MF, Discher DE, Péault BM, Phinney DG, Hare JM, Caplan AI. Mesenchymal stem cell perspective: cell biology to clinical progress. NPJ Regen Med. 2019 Dec 2;4:22. doi: 10.1038/s41536-019-0083-6
  9. ↑ Murphy MB, Moncivais K, Caplan AI. Mesenchymal stem cells: environmentally responsive therapeutics for regenerative medicine. Exp Mol Med. 2013 Nov 15;45(11):e54. doi: 10.1038/emm.2013.94
  10. ↑ Rodríguez-Fuentes DE, Fernández-Garza LE, Samia-Meza JA, Barrera-Barrera SA, Caplan AI, Barrera-Saldaña HA. Mesenchymal Stem Cells Current Clinical Applications: A Systematic Review. Arch Med Res. 2021 Jan;52(1):93-101. doi: 10.1016/j.arcmed.2020.08.006. Epub 2020 Sep 22
Źródło: „http://192.168.110.77:8081/index.php?title=Translations:Mezenchymalne_komórki_macierzyste/1/en&oldid=1190”