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The term homeostasis is used to describe the optimal, stable state of a biological system such as a cell, tissue, organ or whole living organism, which is maintained by strictly regulated physiological processes. Homeostasis is a state of dynamic equilibrium, self-regulating primarily by feedback mechanisms to compensate for changes caused by external agents. Maintenance of homeostasis is related to the fact that the processes of controlled cell death, apoptosis, are balanced by the processes of cell proliferation enhanced by biologically active growth factors.<ref>Nagano K. R-spondin signaling as a pivotal regulator of tissue development and homeostasis. Jpn Dent Sci Rev. 2019 Nov;55(1):80-87. doi: 10.1016/j.jdsr.2019.03.001 </ref> <ref>Karjalainen E, Repasky GA. Molecular Changes During Acute Myeloid Leukemia (AML) Evolution and Identification of Novel Treatment Strategies Through Molecular Stratification. Prog Mol Biol Transl Sci. 2016;144:383-436. doi: 10.1016/bs.pmbts.2016.09.005 </ref>
The term homeostasis is used to describe the optimal, stable state of a biological system such as a cell, tissue, organ or whole living organism, which is maintained by strictly regulated physiological processes. Homeostasis is a state of dynamic equilibrium, self-regulating primarily by feedback mechanisms to compensate for changes caused by external agents. Maintenance of homeostasis is related to the fact that the processes of controlled cell death, apoptosis, are balanced by the processes of cell proliferation enhanced by biologically active [[czynniki wzrostu/en|growth factors]].<ref>Meizlish ML, Franklin RA, Zhou X, Medzhitov R. Tissue Homeostasis and Inflammation. Annu Rev Immunol. 2021 Mar 2. doi: 10.1146/annurev-immunol-061020-053734 </ref> <ref>Klimczak A, Kozlowska U. Mesenchymal Stromal Cells and Tissue-Specific Progenitor Cells: Their Role in Tissue Homeostasis. Stem Cells Int. 2016;2016:4285215. doi: 10.1155/2016/4285215 </ref> <ref>Birbrair A. Stem Cell Microenvironments and Beyond. Adv Exp Med Biol. 2017;1041:1-3. doi: 10.1007/978-3-319-69194-7_1 </ref> <ref>Dyment NA, Galloway JL. Regenerative biology of tendon: mechanisms for renewal and repair. Curr Mol Biol Rep. 2015 Sep;1(3):124-131. doi: 10.1007/s40610-015-0021-3 </ref> <ref>Persa OD, Koester J, Niessen CM. Regulation of Cell Polarity and Tissue Architecture in Epidermal Aging and Cancer. J Invest Dermatol. 2021 Jan 30:S0022-202X(20)32410-6. doi: 10.1016/j.jid.2020.12.012 </ref>

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Tekst źródłowy komunikatu (Homeostaza)
Mianem homeostazy określa się optymalny, stabilny stan układu biologicznego w obrębie komórki, tkanki, narządu, czy całości żywego organizmu, utrzymywany w wyniku ściśle uregulowanych procesów fizjologicznych. Homeostaza jest stanem równowagi dynamicznej, samoregulującym się przede wszystkim poprzez mechanizmy sprzężenia zwrotnego i dążącym do kompensowania zmian wywołanych czynnikami zewnętrznymi. Utrzymanie homeostazy związane jest z faktem, że procesy kontrolowanej śmierci komórki, apoptozy, równoważone są przez procesy proliferacji komórek wspomagane biologicznie aktywnymi [[czynniki wzrostu|czynnikami wzrostowymi]]. <ref>Meizlish ML, Franklin RA, Zhou X, Medzhitov R. Tissue Homeostasis and Inflammation. Annu Rev Immunol. 2021 Mar 2. doi: 10.1146/annurev-immunol-061020-053734 </ref> <ref>Klimczak A, Kozlowska U. Mesenchymal Stromal Cells and Tissue-Specific Progenitor Cells: Their Role in Tissue Homeostasis. Stem Cells Int. 2016;2016:4285215. doi: 10.1155/2016/4285215 </ref> <ref>Birbrair A. Stem Cell Microenvironments and Beyond. Adv Exp Med Biol. 2017;1041:1-3. doi: 10.1007/978-3-319-69194-7_1 </ref> <ref>Dyment NA, Galloway JL. Regenerative biology of tendon: mechanisms for renewal and repair. Curr Mol Biol Rep. 2015 Sep;1(3):124-131. doi: 10.1007/s40610-015-0021-3 </ref> <ref>Persa OD, Koester J, Niessen CM. Regulation of Cell Polarity and Tissue Architecture in Epidermal Aging and Cancer. J Invest Dermatol. 2021 Jan 30:S0022-202X(20)32410-6. doi: 10.1016/j.jid.2020.12.012 </ref>

The term homeostasis is used to describe the optimal, stable state of a biological system such as a cell, tissue, organ or whole living organism, which is maintained by strictly regulated physiological processes. Homeostasis is a state of dynamic equilibrium, self-regulating primarily by feedback mechanisms to compensate for changes caused by external agents. Maintenance of homeostasis is related to the fact that the processes of controlled cell death, apoptosis, are balanced by the processes of cell proliferation enhanced by biologically active growth factors.[1] [2] [3] [4] [5]

  1. ↑ Meizlish ML, Franklin RA, Zhou X, Medzhitov R. Tissue Homeostasis and Inflammation. Annu Rev Immunol. 2021 Mar 2. doi: 10.1146/annurev-immunol-061020-053734
  2. ↑ Klimczak A, Kozlowska U. Mesenchymal Stromal Cells and Tissue-Specific Progenitor Cells: Their Role in Tissue Homeostasis. Stem Cells Int. 2016;2016:4285215. doi: 10.1155/2016/4285215
  3. ↑ Birbrair A. Stem Cell Microenvironments and Beyond. Adv Exp Med Biol. 2017;1041:1-3. doi: 10.1007/978-3-319-69194-7_1
  4. ↑ Dyment NA, Galloway JL. Regenerative biology of tendon: mechanisms for renewal and repair. Curr Mol Biol Rep. 2015 Sep;1(3):124-131. doi: 10.1007/s40610-015-0021-3
  5. ↑ Persa OD, Koester J, Niessen CM. Regulation of Cell Polarity and Tissue Architecture in Epidermal Aging and Cancer. J Invest Dermatol. 2021 Jan 30:S0022-202X(20)32410-6. doi: 10.1016/j.jid.2020.12.012
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