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Agnieszka.krawczenko o 08:31, 22 paź 2021

2021-10-22T08:31:15Z

← poprzednia wersja		Wersja z 08:31, 22 paź 2021
Linia 5:		Linia 5:


	It has been observed [[mezenchymalne komórki macierzyste/en\|mesenchymal stem cells]] (MSCs) have the ability to differentiate into many types of connective tissue, including: bone tissue ([[osteogeneza/en\|osteogenesis]]), cartilage ([[chondrogeneza/en\|chondrogenesis]]), adipose tissue ([[adipogeneza/en\|adipogenesis]]), skeletal muscle tissue (myogenesis), heart muscle (cardiomiogenesis), tendons, ligaments, as well as in ''[[in vitro\|in vitro]]'' tests for nerve tissue cells.<ref>Vazin T, Freed WJ. Human embryonic stem cells: derivation, culture, and differentiation: a review. Restor Neurol Neurosci. 2010;28(4):589-603. doi: 10.3233/RNN-2010-0543</ref> <ref>Kang MI, Kim HS, Jung YC, Kim YH, Hong SJ, Kim MK, Baek KH, Kim CC, Rhyu MG. Transitional CpG methylation between promoters and retroelements of tissue-specific genes during human mesenchymal cell differentiation. J Cell Biochem. 2007 Sep 1;102(1):224-39. doi: 10.1002/jcb.21291</ref> <ref>Gromolak S, Krawczenko A, Antończyk A, Buczak K, Kiełbowicz Z, Klimczak A. Biological Characteristics and Osteogenic Differentiation of Ovine Bone Marrow Derived Mesenchymal Stem Cells Stimulated with FGF-2 and BMP-2. Int J Mol Sci. 2020 Dec 20;21(24):9726. doi: 10.3390/ijms21249726</ref> <ref>Hung BP, Hutton DL, Kozielski KL, Bishop CJ, Naved B, Green JJ, Caplan AI, Gimble JM, Dorafshar AH, Grayson WL. Platelet-Derived Growth Factor BB Enhances Osteogenesis of Adipose-Derived But Not Bone Marrow-Derived Mesenchymal Stromal/Stem Cells. Stem Cells. 2015 Sep;33(9):2773-84. doi: 10.1002/stem.2060. Epub 2015 Jun 26</ref> <ref>Ambele MA, Dhanraj P, Giles R, Pepper MS. Adipogenesis: A Complex Interplay of Multiple Molecular Determinants and Pathways. Int J Mol Sci. 2020 Jun 16;21(12):4283. doi: 10.3390/ijms21124283</ref> <ref>Voskamp C, Koevoet WJLM, Somoza RA, Caplan AI, Lefebvre V, van Osch GJVM, Narcisi R. Enhanced Chondrogenic Capacity of Mesenchymal Stem Cells After TNFα Pre-treatment. Front Bioeng Biotechnol. 2020 Jun 30;8:658. doi: 10.3389/fbioe.2020.00658</ref> <ref>Sorrell JM, Somoza RA, Caplan AI. Human mesenchymal stem cells induced to differentiate as chondrocytes follow a biphasic pattern of extracellular matrix production. J Orthop Res. 2018 Jun;36(6):1757-1766. doi: 10.1002/jor.23820. Epub 2017 Dec 22</ref>.		It has been observed [[mezenchymalne komórki macierzyste/en\|mesenchymal stem cells]] (MSCs) have the ability to differentiate into many types of connective tissue, including: bone tissue ([[osteogeneza/en\|osteogenesis]]), cartilage ([[chondrogeneza/en\|chondrogenesis]]), adipose tissue ([[adipogeneza/en\|adipogenesis]]), skeletal muscle tissue (myogenesis), heart muscle (cardiomiogenesis), tendons, ligaments, as well as in ''[[in vitro/en\|in vitro]]'' tests for nerve tissue cells.<ref>Vazin T, Freed WJ. Human embryonic stem cells: derivation, culture, and differentiation: a review. Restor Neurol Neurosci. 2010;28(4):589-603. doi: 10.3233/RNN-2010-0543</ref> <ref>Kang MI, Kim HS, Jung YC, Kim YH, Hong SJ, Kim MK, Baek KH, Kim CC, Rhyu MG. Transitional CpG methylation between promoters and retroelements of tissue-specific genes during human mesenchymal cell differentiation. J Cell Biochem. 2007 Sep 1;102(1):224-39. doi: 10.1002/jcb.21291</ref> <ref>Gromolak S, Krawczenko A, Antończyk A, Buczak K, Kiełbowicz Z, Klimczak A. Biological Characteristics and Osteogenic Differentiation of Ovine Bone Marrow Derived Mesenchymal Stem Cells Stimulated with FGF-2 and BMP-2. Int J Mol Sci. 2020 Dec 20;21(24):9726. doi: 10.3390/ijms21249726</ref> <ref>Hung BP, Hutton DL, Kozielski KL, Bishop CJ, Naved B, Green JJ, Caplan AI, Gimble JM, Dorafshar AH, Grayson WL. Platelet-Derived Growth Factor BB Enhances Osteogenesis of Adipose-Derived But Not Bone Marrow-Derived Mesenchymal Stromal/Stem Cells. Stem Cells. 2015 Sep;33(9):2773-84. doi: 10.1002/stem.2060. Epub 2015 Jun 26</ref> <ref>Ambele MA, Dhanraj P, Giles R, Pepper MS. Adipogenesis: A Complex Interplay of Multiple Molecular Determinants and Pathways. Int J Mol Sci. 2020 Jun 16;21(12):4283. doi: 10.3390/ijms21124283</ref> <ref>Voskamp C, Koevoet WJLM, Somoza RA, Caplan AI, Lefebvre V, van Osch GJVM, Narcisi R. Enhanced Chondrogenic Capacity of Mesenchymal Stem Cells After TNFα Pre-treatment. Front Bioeng Biotechnol. 2020 Jun 30;8:658. doi: 10.3389/fbioe.2020.00658</ref> <ref>Sorrell JM, Somoza RA, Caplan AI. Human mesenchymal stem cells induced to differentiate as chondrocytes follow a biphasic pattern of extracellular matrix production. J Orthop Res. 2018 Jun;36(6):1757-1766. doi: 10.1002/jor.23820. Epub 2017 Dec 22</ref>.

	=Bibliography=		=Bibliography=

Agnieszka Szyposzyńska o 07:45, 25 cze 2021

2021-06-25T07:45:00Z

← poprzednia wersja		Wersja z 07:45, 25 cze 2021
Linia 5:		Linia 5:


	~~<div class="mw-translate-fuzzy">~~
	It has been observed [[mezenchymalne komórki macierzyste/en\|mesenchymal stem cells]] (MSCs) have the ability to differentiate into many types of connective tissue, including: bone tissue ([[osteogeneza/en\|osteogenesis]]), cartilage ([[chondrogeneza/en\|chondrogenesis]]), adipose tissue ([[adipogeneza/en\|adipogenesis]]), skeletal muscle tissue (myogenesis), heart muscle (cardiomiogenesis), tendons, ligaments, as well as in ''[[in vitro\|in vitro]]'' tests for nerve tissue cells.<ref>Vazin T, Freed WJ. Human embryonic stem cells: derivation, culture, and differentiation: a review. Restor Neurol Neurosci. 2010;28(4):589-603. doi: 10.3233/RNN-2010-0543</ref> <ref>Kang MI, Kim HS, Jung YC, Kim YH, Hong SJ, Kim MK, Baek KH, Kim CC, Rhyu MG. Transitional CpG methylation between promoters and retroelements of tissue-specific genes during human mesenchymal cell differentiation. J Cell Biochem. 2007 Sep 1;102(1):224-39. doi: 10.1002/jcb.21291</ref> <ref>Gromolak S, Krawczenko A, Antończyk A, Buczak K, Kiełbowicz Z, Klimczak A. Biological Characteristics and Osteogenic Differentiation of Ovine Bone Marrow Derived Mesenchymal Stem Cells Stimulated with FGF-2 and BMP-2. Int J Mol Sci. 2020 Dec 20;21(24):9726. doi: 10.3390/ijms21249726</ref> <ref>Hung BP, Hutton DL, Kozielski KL, Bishop CJ, Naved B, Green JJ, Caplan AI, Gimble JM, Dorafshar AH, Grayson WL. Platelet-Derived Growth Factor BB Enhances Osteogenesis of Adipose-Derived But Not Bone Marrow-Derived Mesenchymal Stromal/Stem Cells. Stem Cells. 2015 Sep;33(9):2773-84. doi: 10.1002/stem.2060. Epub 2015 Jun 26</ref> <ref>Ambele MA, Dhanraj P, Giles R, Pepper MS. Adipogenesis: A Complex Interplay of Multiple Molecular Determinants and Pathways. Int J Mol Sci. 2020 Jun 16;21(12):4283. doi: 10.3390/ijms21124283</ref> <ref>Voskamp C, Koevoet WJLM, Somoza RA, Caplan AI, Lefebvre V, van Osch GJVM, Narcisi R. Enhanced Chondrogenic Capacity of Mesenchymal Stem Cells After TNFα Pre-treatment. Front Bioeng Biotechnol. 2020 Jun 30;8:658. doi: 10.3389/fbioe.2020.00658</ref> <ref>Sorrell JM, Somoza RA, Caplan AI. Human mesenchymal stem cells induced to differentiate as chondrocytes follow a biphasic pattern of extracellular matrix production. J Orthop Res. 2018 Jun;36(6):1757-1766. doi: 10.1002/jor.23820. Epub 2017 Dec 22</ref>.		It has been observed [[mezenchymalne komórki macierzyste/en\|mesenchymal stem cells]] (MSCs) have the ability to differentiate into many types of connective tissue, including: bone tissue ([[osteogeneza/en\|osteogenesis]]), cartilage ([[chondrogeneza/en\|chondrogenesis]]), adipose tissue ([[adipogeneza/en\|adipogenesis]]), skeletal muscle tissue (myogenesis), heart muscle (cardiomiogenesis), tendons, ligaments, as well as in ''[[in vitro\|in vitro]]'' tests for nerve tissue cells.<ref>Vazin T, Freed WJ. Human embryonic stem cells: derivation, culture, and differentiation: a review. Restor Neurol Neurosci. 2010;28(4):589-603. doi: 10.3233/RNN-2010-0543</ref> <ref>Kang MI, Kim HS, Jung YC, Kim YH, Hong SJ, Kim MK, Baek KH, Kim CC, Rhyu MG. Transitional CpG methylation between promoters and retroelements of tissue-specific genes during human mesenchymal cell differentiation. J Cell Biochem. 2007 Sep 1;102(1):224-39. doi: 10.1002/jcb.21291</ref> <ref>Gromolak S, Krawczenko A, Antończyk A, Buczak K, Kiełbowicz Z, Klimczak A. Biological Characteristics and Osteogenic Differentiation of Ovine Bone Marrow Derived Mesenchymal Stem Cells Stimulated with FGF-2 and BMP-2. Int J Mol Sci. 2020 Dec 20;21(24):9726. doi: 10.3390/ijms21249726</ref> <ref>Hung BP, Hutton DL, Kozielski KL, Bishop CJ, Naved B, Green JJ, Caplan AI, Gimble JM, Dorafshar AH, Grayson WL. Platelet-Derived Growth Factor BB Enhances Osteogenesis of Adipose-Derived But Not Bone Marrow-Derived Mesenchymal Stromal/Stem Cells. Stem Cells. 2015 Sep;33(9):2773-84. doi: 10.1002/stem.2060. Epub 2015 Jun 26</ref> <ref>Ambele MA, Dhanraj P, Giles R, Pepper MS. Adipogenesis: A Complex Interplay of Multiple Molecular Determinants and Pathways. Int J Mol Sci. 2020 Jun 16;21(12):4283. doi: 10.3390/ijms21124283</ref> <ref>Voskamp C, Koevoet WJLM, Somoza RA, Caplan AI, Lefebvre V, van Osch GJVM, Narcisi R. Enhanced Chondrogenic Capacity of Mesenchymal Stem Cells After TNFα Pre-treatment. Front Bioeng Biotechnol. 2020 Jun 30;8:658. doi: 10.3389/fbioe.2020.00658</ref> <ref>Sorrell JM, Somoza RA, Caplan AI. Human mesenchymal stem cells induced to differentiate as chondrocytes follow a biphasic pattern of extracellular matrix production. J Orthop Res. 2018 Jun;36(6):1757-1766. doi: 10.1002/jor.23820. Epub 2017 Dec 22</ref>.
	~~</div>~~

	=Bibliography=		=Bibliography=

FuzzyBot: Aktualizowanie w celu dopasowania do nowej wersji strony źródłowej

2021-06-25T07:44:29Z

Aktualizowanie w celu dopasowania do nowej wersji strony źródłowej

← poprzednia wersja		Wersja z 07:44, 25 cze 2021
Linia 5:		Linia 5:


			<div class="mw-translate-fuzzy">
	It has been observed [[mezenchymalne komórki macierzyste/en\|mesenchymal stem cells]] (MSCs) have the ability to differentiate into many types of connective tissue, including: bone tissue ([[osteogeneza/en\|osteogenesis]]), cartilage ([[chondrogeneza/en\|chondrogenesis]]), adipose tissue ([[adipogeneza/en\|adipogenesis]]), skeletal muscle tissue (myogenesis), heart muscle (cardiomiogenesis), tendons, ligaments, as well as in ''[[in vitro\|in vitro]]'' tests for nerve tissue cells.<ref>Vazin T, Freed WJ. Human embryonic stem cells: derivation, culture, and differentiation: a review. Restor Neurol Neurosci. 2010;28(4):589-603. doi: 10.3233/RNN-2010-0543</ref> <ref>Kang MI, Kim HS, Jung YC, Kim YH, Hong SJ, Kim MK, Baek KH, Kim CC, Rhyu MG. Transitional CpG methylation between promoters and retroelements of tissue-specific genes during human mesenchymal cell differentiation. J Cell Biochem. 2007 Sep 1;102(1):224-39. doi: 10.1002/jcb.21291</ref> <ref>Gromolak S, Krawczenko A, Antończyk A, Buczak K, Kiełbowicz Z, Klimczak A. Biological Characteristics and Osteogenic Differentiation of Ovine Bone Marrow Derived Mesenchymal Stem Cells Stimulated with FGF-2 and BMP-2. Int J Mol Sci. 2020 Dec 20;21(24):9726. doi: 10.3390/ijms21249726</ref> <ref>Hung BP, Hutton DL, Kozielski KL, Bishop CJ, Naved B, Green JJ, Caplan AI, Gimble JM, Dorafshar AH, Grayson WL. Platelet-Derived Growth Factor BB Enhances Osteogenesis of Adipose-Derived But Not Bone Marrow-Derived Mesenchymal Stromal/Stem Cells. Stem Cells. 2015 Sep;33(9):2773-84. doi: 10.1002/stem.2060. Epub 2015 Jun 26</ref> <ref>Ambele MA, Dhanraj P, Giles R, Pepper MS. Adipogenesis: A Complex Interplay of Multiple Molecular Determinants and Pathways. Int J Mol Sci. 2020 Jun 16;21(12):4283. doi: 10.3390/ijms21124283</ref> <ref>Voskamp C, Koevoet WJLM, Somoza RA, Caplan AI, Lefebvre V, van Osch GJVM, Narcisi R. Enhanced Chondrogenic Capacity of Mesenchymal Stem Cells After TNFα Pre-treatment. Front Bioeng Biotechnol. 2020 Jun 30;8:658. doi: 10.3389/fbioe.2020.00658</ref> <ref>Sorrell JM, Somoza RA, Caplan AI. Human mesenchymal stem cells induced to differentiate as chondrocytes follow a biphasic pattern of extracellular matrix production. J Orthop Res. 2018 Jun;36(6):1757-1766. doi: 10.1002/jor.23820. Epub 2017 Dec 22</ref>.		It has been observed [[mezenchymalne komórki macierzyste/en\|mesenchymal stem cells]] (MSCs) have the ability to differentiate into many types of connective tissue, including: bone tissue ([[osteogeneza/en\|osteogenesis]]), cartilage ([[chondrogeneza/en\|chondrogenesis]]), adipose tissue ([[adipogeneza/en\|adipogenesis]]), skeletal muscle tissue (myogenesis), heart muscle (cardiomiogenesis), tendons, ligaments, as well as in ''[[in vitro\|in vitro]]'' tests for nerve tissue cells.<ref>Vazin T, Freed WJ. Human embryonic stem cells: derivation, culture, and differentiation: a review. Restor Neurol Neurosci. 2010;28(4):589-603. doi: 10.3233/RNN-2010-0543</ref> <ref>Kang MI, Kim HS, Jung YC, Kim YH, Hong SJ, Kim MK, Baek KH, Kim CC, Rhyu MG. Transitional CpG methylation between promoters and retroelements of tissue-specific genes during human mesenchymal cell differentiation. J Cell Biochem. 2007 Sep 1;102(1):224-39. doi: 10.1002/jcb.21291</ref> <ref>Gromolak S, Krawczenko A, Antończyk A, Buczak K, Kiełbowicz Z, Klimczak A. Biological Characteristics and Osteogenic Differentiation of Ovine Bone Marrow Derived Mesenchymal Stem Cells Stimulated with FGF-2 and BMP-2. Int J Mol Sci. 2020 Dec 20;21(24):9726. doi: 10.3390/ijms21249726</ref> <ref>Hung BP, Hutton DL, Kozielski KL, Bishop CJ, Naved B, Green JJ, Caplan AI, Gimble JM, Dorafshar AH, Grayson WL. Platelet-Derived Growth Factor BB Enhances Osteogenesis of Adipose-Derived But Not Bone Marrow-Derived Mesenchymal Stromal/Stem Cells. Stem Cells. 2015 Sep;33(9):2773-84. doi: 10.1002/stem.2060. Epub 2015 Jun 26</ref> <ref>Ambele MA, Dhanraj P, Giles R, Pepper MS. Adipogenesis: A Complex Interplay of Multiple Molecular Determinants and Pathways. Int J Mol Sci. 2020 Jun 16;21(12):4283. doi: 10.3390/ijms21124283</ref> <ref>Voskamp C, Koevoet WJLM, Somoza RA, Caplan AI, Lefebvre V, van Osch GJVM, Narcisi R. Enhanced Chondrogenic Capacity of Mesenchymal Stem Cells After TNFα Pre-treatment. Front Bioeng Biotechnol. 2020 Jun 30;8:658. doi: 10.3389/fbioe.2020.00658</ref> <ref>Sorrell JM, Somoza RA, Caplan AI. Human mesenchymal stem cells induced to differentiate as chondrocytes follow a biphasic pattern of extracellular matrix production. J Orthop Res. 2018 Jun;36(6):1757-1766. doi: 10.1002/jor.23820. Epub 2017 Dec 22</ref>.
			</div>

	=Bibliography=		=Bibliography=

Agnieszka Szyposzyńska o 13:41, 19 maj 2021

2021-05-19T13:41:19Z

← poprzednia wersja		Wersja z 13:41, 19 maj 2021
Linia 5:		Linia 5:


	It has been observed [[mezenchymalne komórki ~~maxcierzyste~~/en\|mesenchymal stem cells]] (MSCs) have the ability to differentiate into many types of connective tissue, including: bone tissue ([[osteogeneza/en\|osteogenesis]]), cartilage ([[chondrogeneza/en\|chondrogenesis]]), adipose tissue ([[adipogeneza/en\|adipogenesis]]), skeletal muscle tissue (myogenesis), heart muscle (cardiomiogenesis), tendons, ligaments, as well as in ''[[in vitro\|in vitro]]'' tests for nerve tissue cells.<ref>Vazin T, Freed WJ. Human embryonic stem cells: derivation, culture, and differentiation: a review. Restor Neurol Neurosci. 2010;28(4):589-603. doi: 10.3233/RNN-2010-0543</ref> <ref>Kang MI, Kim HS, Jung YC, Kim YH, Hong SJ, Kim MK, Baek KH, Kim CC, Rhyu MG. Transitional CpG methylation between promoters and retroelements of tissue-specific genes during human mesenchymal cell differentiation. J Cell Biochem. 2007 Sep 1;102(1):224-39. doi: 10.1002/jcb.21291</ref> <ref>Gromolak S, Krawczenko A, Antończyk A, Buczak K, Kiełbowicz Z, Klimczak A. Biological Characteristics and Osteogenic Differentiation of Ovine Bone Marrow Derived Mesenchymal Stem Cells Stimulated with FGF-2 and BMP-2. Int J Mol Sci. 2020 Dec 20;21(24):9726. doi: 10.3390/ijms21249726</ref> <ref>Hung BP, Hutton DL, Kozielski KL, Bishop CJ, Naved B, Green JJ, Caplan AI, Gimble JM, Dorafshar AH, Grayson WL. Platelet-Derived Growth Factor BB Enhances Osteogenesis of Adipose-Derived But Not Bone Marrow-Derived Mesenchymal Stromal/Stem Cells. Stem Cells. 2015 Sep;33(9):2773-84. doi: 10.1002/stem.2060. Epub 2015 Jun 26</ref> <ref>Ambele MA, Dhanraj P, Giles R, Pepper MS. Adipogenesis: A Complex Interplay of Multiple Molecular Determinants and Pathways. Int J Mol Sci. 2020 Jun 16;21(12):4283. doi: 10.3390/ijms21124283</ref> <ref>Voskamp C, Koevoet WJLM, Somoza RA, Caplan AI, Lefebvre V, van Osch GJVM, Narcisi R. Enhanced Chondrogenic Capacity of Mesenchymal Stem Cells After TNFα Pre-treatment. Front Bioeng Biotechnol. 2020 Jun 30;8:658. doi: 10.3389/fbioe.2020.00658</ref> <ref>Sorrell JM, Somoza RA, Caplan AI. Human mesenchymal stem cells induced to differentiate as chondrocytes follow a biphasic pattern of extracellular matrix production. J Orthop Res. 2018 Jun;36(6):1757-1766. doi: 10.1002/jor.23820. Epub 2017 Dec 22</ref>.		It has been observed [[mezenchymalne komórki macierzyste/en\|mesenchymal stem cells]] (MSCs) have the ability to differentiate into many types of connective tissue, including: bone tissue ([[osteogeneza/en\|osteogenesis]]), cartilage ([[chondrogeneza/en\|chondrogenesis]]), adipose tissue ([[adipogeneza/en\|adipogenesis]]), skeletal muscle tissue (myogenesis), heart muscle (cardiomiogenesis), tendons, ligaments, as well as in ''[[in vitro\|in vitro]]'' tests for nerve tissue cells.<ref>Vazin T, Freed WJ. Human embryonic stem cells: derivation, culture, and differentiation: a review. Restor Neurol Neurosci. 2010;28(4):589-603. doi: 10.3233/RNN-2010-0543</ref> <ref>Kang MI, Kim HS, Jung YC, Kim YH, Hong SJ, Kim MK, Baek KH, Kim CC, Rhyu MG. Transitional CpG methylation between promoters and retroelements of tissue-specific genes during human mesenchymal cell differentiation. J Cell Biochem. 2007 Sep 1;102(1):224-39. doi: 10.1002/jcb.21291</ref> <ref>Gromolak S, Krawczenko A, Antończyk A, Buczak K, Kiełbowicz Z, Klimczak A. Biological Characteristics and Osteogenic Differentiation of Ovine Bone Marrow Derived Mesenchymal Stem Cells Stimulated with FGF-2 and BMP-2. Int J Mol Sci. 2020 Dec 20;21(24):9726. doi: 10.3390/ijms21249726</ref> <ref>Hung BP, Hutton DL, Kozielski KL, Bishop CJ, Naved B, Green JJ, Caplan AI, Gimble JM, Dorafshar AH, Grayson WL. Platelet-Derived Growth Factor BB Enhances Osteogenesis of Adipose-Derived But Not Bone Marrow-Derived Mesenchymal Stromal/Stem Cells. Stem Cells. 2015 Sep;33(9):2773-84. doi: 10.1002/stem.2060. Epub 2015 Jun 26</ref> <ref>Ambele MA, Dhanraj P, Giles R, Pepper MS. Adipogenesis: A Complex Interplay of Multiple Molecular Determinants and Pathways. Int J Mol Sci. 2020 Jun 16;21(12):4283. doi: 10.3390/ijms21124283</ref> <ref>Voskamp C, Koevoet WJLM, Somoza RA, Caplan AI, Lefebvre V, van Osch GJVM, Narcisi R. Enhanced Chondrogenic Capacity of Mesenchymal Stem Cells After TNFα Pre-treatment. Front Bioeng Biotechnol. 2020 Jun 30;8:658. doi: 10.3389/fbioe.2020.00658</ref> <ref>Sorrell JM, Somoza RA, Caplan AI. Human mesenchymal stem cells induced to differentiate as chondrocytes follow a biphasic pattern of extracellular matrix production. J Orthop Res. 2018 Jun;36(6):1757-1766. doi: 10.1002/jor.23820. Epub 2017 Dec 22</ref>.

	=Bibliography=		=Bibliography=

Agnieszka Szyposzyńska o 13:40, 19 maj 2021

2021-05-19T13:40:11Z

← poprzednia wersja		Wersja z 13:40, 19 maj 2021
Linia 5:		Linia 5:


	It has been observed ~~mesenchymal stem cells (~~[[~~MSC~~/en\|~~MSCs~~]]) have the ability to differentiate into many types of connective tissue, including: bone tissue ([[osteogeneza/en\|osteogenesis]]), cartilage ([[chondrogeneza/en\|chondrogenesis]]), adipose tissue ([[adipogeneza/en\|adipogenesis]]), skeletal muscle tissue (myogenesis), heart muscle (cardiomiogenesis), tendons, ligaments, as well as in ''[[in vitro\|in vitro]]'' tests for nerve tissue cells.<ref>Vazin T, Freed WJ. Human embryonic stem cells: derivation, culture, and differentiation: a review. Restor Neurol Neurosci. 2010;28(4):589-603. doi: 10.3233/RNN-2010-0543</ref> <ref>Kang MI, Kim HS, Jung YC, Kim YH, Hong SJ, Kim MK, Baek KH, Kim CC, Rhyu MG. Transitional CpG methylation between promoters and retroelements of tissue-specific genes during human mesenchymal cell differentiation. J Cell Biochem. 2007 Sep 1;102(1):224-39. doi: 10.1002/jcb.21291</ref> <ref>Gromolak S, Krawczenko A, Antończyk A, Buczak K, Kiełbowicz Z, Klimczak A. Biological Characteristics and Osteogenic Differentiation of Ovine Bone Marrow Derived Mesenchymal Stem Cells Stimulated with FGF-2 and BMP-2. Int J Mol Sci. 2020 Dec 20;21(24):9726. doi: 10.3390/ijms21249726</ref> <ref>Hung BP, Hutton DL, Kozielski KL, Bishop CJ, Naved B, Green JJ, Caplan AI, Gimble JM, Dorafshar AH, Grayson WL. Platelet-Derived Growth Factor BB Enhances Osteogenesis of Adipose-Derived But Not Bone Marrow-Derived Mesenchymal Stromal/Stem Cells. Stem Cells. 2015 Sep;33(9):2773-84. doi: 10.1002/stem.2060. Epub 2015 Jun 26</ref> <ref>Ambele MA, Dhanraj P, Giles R, Pepper MS. Adipogenesis: A Complex Interplay of Multiple Molecular Determinants and Pathways. Int J Mol Sci. 2020 Jun 16;21(12):4283. doi: 10.3390/ijms21124283</ref> <ref>Voskamp C, Koevoet WJLM, Somoza RA, Caplan AI, Lefebvre V, van Osch GJVM, Narcisi R. Enhanced Chondrogenic Capacity of Mesenchymal Stem Cells After TNFα Pre-treatment. Front Bioeng Biotechnol. 2020 Jun 30;8:658. doi: 10.3389/fbioe.2020.00658</ref> <ref>Sorrell JM, Somoza RA, Caplan AI. Human mesenchymal stem cells induced to differentiate as chondrocytes follow a biphasic pattern of extracellular matrix production. J Orthop Res. 2018 Jun;36(6):1757-1766. doi: 10.1002/jor.23820. Epub 2017 Dec 22</ref>.		It has been observed [[mezenchymalne komórki maxcierzyste/en\|mesenchymal stem cells]] (MSCs) have the ability to differentiate into many types of connective tissue, including: bone tissue ([[osteogeneza/en\|osteogenesis]]), cartilage ([[chondrogeneza/en\|chondrogenesis]]), adipose tissue ([[adipogeneza/en\|adipogenesis]]), skeletal muscle tissue (myogenesis), heart muscle (cardiomiogenesis), tendons, ligaments, as well as in ''[[in vitro\|in vitro]]'' tests for nerve tissue cells.<ref>Vazin T, Freed WJ. Human embryonic stem cells: derivation, culture, and differentiation: a review. Restor Neurol Neurosci. 2010;28(4):589-603. doi: 10.3233/RNN-2010-0543</ref> <ref>Kang MI, Kim HS, Jung YC, Kim YH, Hong SJ, Kim MK, Baek KH, Kim CC, Rhyu MG. Transitional CpG methylation between promoters and retroelements of tissue-specific genes during human mesenchymal cell differentiation. J Cell Biochem. 2007 Sep 1;102(1):224-39. doi: 10.1002/jcb.21291</ref> <ref>Gromolak S, Krawczenko A, Antończyk A, Buczak K, Kiełbowicz Z, Klimczak A. Biological Characteristics and Osteogenic Differentiation of Ovine Bone Marrow Derived Mesenchymal Stem Cells Stimulated with FGF-2 and BMP-2. Int J Mol Sci. 2020 Dec 20;21(24):9726. doi: 10.3390/ijms21249726</ref> <ref>Hung BP, Hutton DL, Kozielski KL, Bishop CJ, Naved B, Green JJ, Caplan AI, Gimble JM, Dorafshar AH, Grayson WL. Platelet-Derived Growth Factor BB Enhances Osteogenesis of Adipose-Derived But Not Bone Marrow-Derived Mesenchymal Stromal/Stem Cells. Stem Cells. 2015 Sep;33(9):2773-84. doi: 10.1002/stem.2060. Epub 2015 Jun 26</ref> <ref>Ambele MA, Dhanraj P, Giles R, Pepper MS. Adipogenesis: A Complex Interplay of Multiple Molecular Determinants and Pathways. Int J Mol Sci. 2020 Jun 16;21(12):4283. doi: 10.3390/ijms21124283</ref> <ref>Voskamp C, Koevoet WJLM, Somoza RA, Caplan AI, Lefebvre V, van Osch GJVM, Narcisi R. Enhanced Chondrogenic Capacity of Mesenchymal Stem Cells After TNFα Pre-treatment. Front Bioeng Biotechnol. 2020 Jun 30;8:658. doi: 10.3389/fbioe.2020.00658</ref> <ref>Sorrell JM, Somoza RA, Caplan AI. Human mesenchymal stem cells induced to differentiate as chondrocytes follow a biphasic pattern of extracellular matrix production. J Orthop Res. 2018 Jun;36(6):1757-1766. doi: 10.1002/jor.23820. Epub 2017 Dec 22</ref>.

	=Bibliography=		=Bibliography=

Agnieszka Szyposzyńska o 13:16, 27 kwi 2021

2021-04-27T13:16:35Z

← poprzednia wersja		Wersja z 13:16, 27 kwi 2021
Linia 5:		Linia 5:


	It has been observed mesenchymal stem cells ([[MSC/en\|MSCs]]) have the ability to differentiate into many types of connective tissue, including: bone tissue ([[osteogeneza/en\|osteogenesis]]), cartilage ([[chondrogeneza/en\|chondrogenesis]]), adipose tissue ([[adipogeneza/en\|adipogenesis]]), skeletal muscle tissue (myogenesis), heart muscle (cardiomiogenesis), tendons, ligaments, as well as in [[''in vitro~~''/en~~\|''in vitro'']] tests for nerve tissue cells.<ref>Vazin T, Freed WJ. Human embryonic stem cells: derivation, culture, and differentiation: a review. Restor Neurol Neurosci. 2010;28(4):589-603. doi: 10.3233/RNN-2010-0543</ref> <ref>Kang MI, Kim HS, Jung YC, Kim YH, Hong SJ, Kim MK, Baek KH, Kim CC, Rhyu MG. Transitional CpG methylation between promoters and retroelements of tissue-specific genes during human mesenchymal cell differentiation. J Cell Biochem. 2007 Sep 1;102(1):224-39. doi: 10.1002/jcb.21291</ref> <ref>Gromolak S, Krawczenko A, Antończyk A, Buczak K, Kiełbowicz Z, Klimczak A. Biological Characteristics and Osteogenic Differentiation of Ovine Bone Marrow Derived Mesenchymal Stem Cells Stimulated with FGF-2 and BMP-2. Int J Mol Sci. 2020 Dec 20;21(24):9726. doi: 10.3390/ijms21249726</ref> <ref>Hung BP, Hutton DL, Kozielski KL, Bishop CJ, Naved B, Green JJ, Caplan AI, Gimble JM, Dorafshar AH, Grayson WL. Platelet-Derived Growth Factor BB Enhances Osteogenesis of Adipose-Derived But Not Bone Marrow-Derived Mesenchymal Stromal/Stem Cells. Stem Cells. 2015 Sep;33(9):2773-84. doi: 10.1002/stem.2060. Epub 2015 Jun 26</ref> <ref>Ambele MA, Dhanraj P, Giles R, Pepper MS. Adipogenesis: A Complex Interplay of Multiple Molecular Determinants and Pathways. Int J Mol Sci. 2020 Jun 16;21(12):4283. doi: 10.3390/ijms21124283</ref> <ref>Voskamp C, Koevoet WJLM, Somoza RA, Caplan AI, Lefebvre V, van Osch GJVM, Narcisi R. Enhanced Chondrogenic Capacity of Mesenchymal Stem Cells After TNFα Pre-treatment. Front Bioeng Biotechnol. 2020 Jun 30;8:658. doi: 10.3389/fbioe.2020.00658</ref> <ref>Sorrell JM, Somoza RA, Caplan AI. Human mesenchymal stem cells induced to differentiate as chondrocytes follow a biphasic pattern of extracellular matrix production. J Orthop Res. 2018 Jun;36(6):1757-1766. doi: 10.1002/jor.23820. Epub 2017 Dec 22</ref>.		It has been observed mesenchymal stem cells ([[MSC/en\|MSCs]]) have the ability to differentiate into many types of connective tissue, including: bone tissue ([[osteogeneza/en\|osteogenesis]]), cartilage ([[chondrogeneza/en\|chondrogenesis]]), adipose tissue ([[adipogeneza/en\|adipogenesis]]), skeletal muscle tissue (myogenesis), heart muscle (cardiomiogenesis), tendons, ligaments, as well as in ''[[in vitro\|in vitro]]'' tests for nerve tissue cells.<ref>Vazin T, Freed WJ. Human embryonic stem cells: derivation, culture, and differentiation: a review. Restor Neurol Neurosci. 2010;28(4):589-603. doi: 10.3233/RNN-2010-0543</ref> <ref>Kang MI, Kim HS, Jung YC, Kim YH, Hong SJ, Kim MK, Baek KH, Kim CC, Rhyu MG. Transitional CpG methylation between promoters and retroelements of tissue-specific genes during human mesenchymal cell differentiation. J Cell Biochem. 2007 Sep 1;102(1):224-39. doi: 10.1002/jcb.21291</ref> <ref>Gromolak S, Krawczenko A, Antończyk A, Buczak K, Kiełbowicz Z, Klimczak A. Biological Characteristics and Osteogenic Differentiation of Ovine Bone Marrow Derived Mesenchymal Stem Cells Stimulated with FGF-2 and BMP-2. Int J Mol Sci. 2020 Dec 20;21(24):9726. doi: 10.3390/ijms21249726</ref> <ref>Hung BP, Hutton DL, Kozielski KL, Bishop CJ, Naved B, Green JJ, Caplan AI, Gimble JM, Dorafshar AH, Grayson WL. Platelet-Derived Growth Factor BB Enhances Osteogenesis of Adipose-Derived But Not Bone Marrow-Derived Mesenchymal Stromal/Stem Cells. Stem Cells. 2015 Sep;33(9):2773-84. doi: 10.1002/stem.2060. Epub 2015 Jun 26</ref> <ref>Ambele MA, Dhanraj P, Giles R, Pepper MS. Adipogenesis: A Complex Interplay of Multiple Molecular Determinants and Pathways. Int J Mol Sci. 2020 Jun 16;21(12):4283. doi: 10.3390/ijms21124283</ref> <ref>Voskamp C, Koevoet WJLM, Somoza RA, Caplan AI, Lefebvre V, van Osch GJVM, Narcisi R. Enhanced Chondrogenic Capacity of Mesenchymal Stem Cells After TNFα Pre-treatment. Front Bioeng Biotechnol. 2020 Jun 30;8:658. doi: 10.3389/fbioe.2020.00658</ref> <ref>Sorrell JM, Somoza RA, Caplan AI. Human mesenchymal stem cells induced to differentiate as chondrocytes follow a biphasic pattern of extracellular matrix production. J Orthop Res. 2018 Jun;36(6):1757-1766. doi: 10.1002/jor.23820. Epub 2017 Dec 22</ref>.

	=Bibliography=		=Bibliography=

Agnieszka Szyposzyńska o 13:15, 27 kwi 2021

2021-04-27T13:15:19Z

← poprzednia wersja		Wersja z 13:15, 27 kwi 2021
Linia 5:		Linia 5:


	It has been observed mesenchymal stem cells ([[MSC/en\|MSCs]]) have the ability to differentiate into many types of connective tissue, including: bone tissue ([[osteogeneza/en\|osteogenesis]]), cartilage ([[chondrogeneza/en\|chondrogenesis]]), adipose tissue ([[adipogeneza/en\|adipogenesis]]), skeletal muscle tissue (myogenesis), heart muscle (cardiomiogenesis), tendons, ligaments, as well as in ''in vitro'' tests for nerve tissue cells.<ref>Vazin T, Freed WJ. Human embryonic stem cells: derivation, culture, and differentiation: a review. Restor Neurol Neurosci. 2010;28(4):589-603. doi: 10.3233/RNN-2010-0543</ref> <ref>Kang MI, Kim HS, Jung YC, Kim YH, Hong SJ, Kim MK, Baek KH, Kim CC, Rhyu MG. Transitional CpG methylation between promoters and retroelements of tissue-specific genes during human mesenchymal cell differentiation. J Cell Biochem. 2007 Sep 1;102(1):224-39. doi: 10.1002/jcb.21291</ref> <ref>Gromolak S, Krawczenko A, Antończyk A, Buczak K, Kiełbowicz Z, Klimczak A. Biological Characteristics and Osteogenic Differentiation of Ovine Bone Marrow Derived Mesenchymal Stem Cells Stimulated with FGF-2 and BMP-2. Int J Mol Sci. 2020 Dec 20;21(24):9726. doi: 10.3390/ijms21249726</ref> <ref>Hung BP, Hutton DL, Kozielski KL, Bishop CJ, Naved B, Green JJ, Caplan AI, Gimble JM, Dorafshar AH, Grayson WL. Platelet-Derived Growth Factor BB Enhances Osteogenesis of Adipose-Derived But Not Bone Marrow-Derived Mesenchymal Stromal/Stem Cells. Stem Cells. 2015 Sep;33(9):2773-84. doi: 10.1002/stem.2060. Epub 2015 Jun 26</ref> <ref>Ambele MA, Dhanraj P, Giles R, Pepper MS. Adipogenesis: A Complex Interplay of Multiple Molecular Determinants and Pathways. Int J Mol Sci. 2020 Jun 16;21(12):4283. doi: 10.3390/ijms21124283</ref> <ref>Voskamp C, Koevoet WJLM, Somoza RA, Caplan AI, Lefebvre V, van Osch GJVM, Narcisi R. Enhanced Chondrogenic Capacity of Mesenchymal Stem Cells After TNFα Pre-treatment. Front Bioeng Biotechnol. 2020 Jun 30;8:658. doi: 10.3389/fbioe.2020.00658</ref> <ref>Sorrell JM, Somoza RA, Caplan AI. Human mesenchymal stem cells induced to differentiate as chondrocytes follow a biphasic pattern of extracellular matrix production. J Orthop Res. 2018 Jun;36(6):1757-1766. doi: 10.1002/jor.23820. Epub 2017 Dec 22</ref>.		It has been observed mesenchymal stem cells ([[MSC/en\|MSCs]]) have the ability to differentiate into many types of connective tissue, including: bone tissue ([[osteogeneza/en\|osteogenesis]]), cartilage ([[chondrogeneza/en\|chondrogenesis]]), adipose tissue ([[adipogeneza/en\|adipogenesis]]), skeletal muscle tissue (myogenesis), heart muscle (cardiomiogenesis), tendons, ligaments, as well as in [[''in vitro''/en\|''in vitro'']] tests for nerve tissue cells.<ref>Vazin T, Freed WJ. Human embryonic stem cells: derivation, culture, and differentiation: a review. Restor Neurol Neurosci. 2010;28(4):589-603. doi: 10.3233/RNN-2010-0543</ref> <ref>Kang MI, Kim HS, Jung YC, Kim YH, Hong SJ, Kim MK, Baek KH, Kim CC, Rhyu MG. Transitional CpG methylation between promoters and retroelements of tissue-specific genes during human mesenchymal cell differentiation. J Cell Biochem. 2007 Sep 1;102(1):224-39. doi: 10.1002/jcb.21291</ref> <ref>Gromolak S, Krawczenko A, Antończyk A, Buczak K, Kiełbowicz Z, Klimczak A. Biological Characteristics and Osteogenic Differentiation of Ovine Bone Marrow Derived Mesenchymal Stem Cells Stimulated with FGF-2 and BMP-2. Int J Mol Sci. 2020 Dec 20;21(24):9726. doi: 10.3390/ijms21249726</ref> <ref>Hung BP, Hutton DL, Kozielski KL, Bishop CJ, Naved B, Green JJ, Caplan AI, Gimble JM, Dorafshar AH, Grayson WL. Platelet-Derived Growth Factor BB Enhances Osteogenesis of Adipose-Derived But Not Bone Marrow-Derived Mesenchymal Stromal/Stem Cells. Stem Cells. 2015 Sep;33(9):2773-84. doi: 10.1002/stem.2060. Epub 2015 Jun 26</ref> <ref>Ambele MA, Dhanraj P, Giles R, Pepper MS. Adipogenesis: A Complex Interplay of Multiple Molecular Determinants and Pathways. Int J Mol Sci. 2020 Jun 16;21(12):4283. doi: 10.3390/ijms21124283</ref> <ref>Voskamp C, Koevoet WJLM, Somoza RA, Caplan AI, Lefebvre V, van Osch GJVM, Narcisi R. Enhanced Chondrogenic Capacity of Mesenchymal Stem Cells After TNFα Pre-treatment. Front Bioeng Biotechnol. 2020 Jun 30;8:658. doi: 10.3389/fbioe.2020.00658</ref> <ref>Sorrell JM, Somoza RA, Caplan AI. Human mesenchymal stem cells induced to differentiate as chondrocytes follow a biphasic pattern of extracellular matrix production. J Orthop Res. 2018 Jun;36(6):1757-1766. doi: 10.1002/jor.23820. Epub 2017 Dec 22</ref>.

	=Bibliography=		=Bibliography=

Agnieszka Szyposzyńska o 13:12, 27 kwi 2021

2021-04-27T13:12:48Z

← poprzednia wersja		Wersja z 13:12, 27 kwi 2021
Linia 5:		Linia 5:


	It has been observed mesenchymal stem cells ([[MSC/en\|MSCs]]) have the ability to differentiate into many types of connective tissue, including: bone tissue ([[osteogeneza/en\|osteogenesis]]), cartilage ([[chondrogeneza/en\|chondrogenesis]]), adipose tissue ([[adipogeneza/en\|adipogenesis]]), skeletal muscle tissue (myogenesis), heart muscle (cardiomiogenesis), tendons, ligaments, as well as in in vitro tests for nerve tissue cells.<ref>Vazin T, Freed WJ. Human embryonic stem cells: derivation, culture, and differentiation: a review. Restor Neurol Neurosci. 2010;28(4):589-603. doi: 10.3233/RNN-2010-0543</ref> <ref>Kang MI, Kim HS, Jung YC, Kim YH, Hong SJ, Kim MK, Baek KH, Kim CC, Rhyu MG. Transitional CpG methylation between promoters and retroelements of tissue-specific genes during human mesenchymal cell differentiation. J Cell Biochem. 2007 Sep 1;102(1):224-39. doi: 10.1002/jcb.21291</ref> <ref>Gromolak S, Krawczenko A, Antończyk A, Buczak K, Kiełbowicz Z, Klimczak A. Biological Characteristics and Osteogenic Differentiation of Ovine Bone Marrow Derived Mesenchymal Stem Cells Stimulated with FGF-2 and BMP-2. Int J Mol Sci. 2020 Dec 20;21(24):9726. doi: 10.3390/ijms21249726</ref> <ref>Hung BP, Hutton DL, Kozielski KL, Bishop CJ, Naved B, Green JJ, Caplan AI, Gimble JM, Dorafshar AH, Grayson WL. Platelet-Derived Growth Factor BB Enhances Osteogenesis of Adipose-Derived But Not Bone Marrow-Derived Mesenchymal Stromal/Stem Cells. Stem Cells. 2015 Sep;33(9):2773-84. doi: 10.1002/stem.2060. Epub 2015 Jun 26</ref> <ref>Ambele MA, Dhanraj P, Giles R, Pepper MS. Adipogenesis: A Complex Interplay of Multiple Molecular Determinants and Pathways. Int J Mol Sci. 2020 Jun 16;21(12):4283. doi: 10.3390/ijms21124283</ref> <ref>Voskamp C, Koevoet WJLM, Somoza RA, Caplan AI, Lefebvre V, van Osch GJVM, Narcisi R. Enhanced Chondrogenic Capacity of Mesenchymal Stem Cells After TNFα Pre-treatment. Front Bioeng Biotechnol. 2020 Jun 30;8:658. doi: 10.3389/fbioe.2020.00658</ref> <ref>Sorrell JM, Somoza RA, Caplan AI. Human mesenchymal stem cells induced to differentiate as chondrocytes follow a biphasic pattern of extracellular matrix production. J Orthop Res. 2018 Jun;36(6):1757-1766. doi: 10.1002/jor.23820. Epub 2017 Dec 22</ref>.		It has been observed mesenchymal stem cells ([[MSC/en\|MSCs]]) have the ability to differentiate into many types of connective tissue, including: bone tissue ([[osteogeneza/en\|osteogenesis]]), cartilage ([[chondrogeneza/en\|chondrogenesis]]), adipose tissue ([[adipogeneza/en\|adipogenesis]]), skeletal muscle tissue (myogenesis), heart muscle (cardiomiogenesis), tendons, ligaments, as well as in ''in vitro'' tests for nerve tissue cells.<ref>Vazin T, Freed WJ. Human embryonic stem cells: derivation, culture, and differentiation: a review. Restor Neurol Neurosci. 2010;28(4):589-603. doi: 10.3233/RNN-2010-0543</ref> <ref>Kang MI, Kim HS, Jung YC, Kim YH, Hong SJ, Kim MK, Baek KH, Kim CC, Rhyu MG. Transitional CpG methylation between promoters and retroelements of tissue-specific genes during human mesenchymal cell differentiation. J Cell Biochem. 2007 Sep 1;102(1):224-39. doi: 10.1002/jcb.21291</ref> <ref>Gromolak S, Krawczenko A, Antończyk A, Buczak K, Kiełbowicz Z, Klimczak A. Biological Characteristics and Osteogenic Differentiation of Ovine Bone Marrow Derived Mesenchymal Stem Cells Stimulated with FGF-2 and BMP-2. Int J Mol Sci. 2020 Dec 20;21(24):9726. doi: 10.3390/ijms21249726</ref> <ref>Hung BP, Hutton DL, Kozielski KL, Bishop CJ, Naved B, Green JJ, Caplan AI, Gimble JM, Dorafshar AH, Grayson WL. Platelet-Derived Growth Factor BB Enhances Osteogenesis of Adipose-Derived But Not Bone Marrow-Derived Mesenchymal Stromal/Stem Cells. Stem Cells. 2015 Sep;33(9):2773-84. doi: 10.1002/stem.2060. Epub 2015 Jun 26</ref> <ref>Ambele MA, Dhanraj P, Giles R, Pepper MS. Adipogenesis: A Complex Interplay of Multiple Molecular Determinants and Pathways. Int J Mol Sci. 2020 Jun 16;21(12):4283. doi: 10.3390/ijms21124283</ref> <ref>Voskamp C, Koevoet WJLM, Somoza RA, Caplan AI, Lefebvre V, van Osch GJVM, Narcisi R. Enhanced Chondrogenic Capacity of Mesenchymal Stem Cells After TNFα Pre-treatment. Front Bioeng Biotechnol. 2020 Jun 30;8:658. doi: 10.3389/fbioe.2020.00658</ref> <ref>Sorrell JM, Somoza RA, Caplan AI. Human mesenchymal stem cells induced to differentiate as chondrocytes follow a biphasic pattern of extracellular matrix production. J Orthop Res. 2018 Jun;36(6):1757-1766. doi: 10.1002/jor.23820. Epub 2017 Dec 22</ref>.

	=Bibliography=		=Bibliography=

Agnieszka Szyposzyńska: Utworzono nową stronę "=Bibliography="

2021-04-27T13:10:29Z

Utworzono nową stronę "=Bibliography="

← poprzednia wersja		Wersja z 13:10, 27 kwi 2021
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	It has been observed mesenchymal stem cells ([[MSC/en\|MSCs]]) have the ability to differentiate into many types of connective tissue, including: bone tissue ([[osteogeneza/en\|osteogenesis]]), cartilage ([[chondrogeneza/en\|chondrogenesis]]), adipose tissue ([[adipogeneza/en\|adipogenesis]]), skeletal muscle tissue (myogenesis), heart muscle (cardiomiogenesis), tendons, ligaments, as well as in in vitro tests for nerve tissue cells.<ref>Vazin T, Freed WJ. Human embryonic stem cells: derivation, culture, and differentiation: a review. Restor Neurol Neurosci. 2010;28(4):589-603. doi: 10.3233/RNN-2010-0543</ref> <ref>Kang MI, Kim HS, Jung YC, Kim YH, Hong SJ, Kim MK, Baek KH, Kim CC, Rhyu MG. Transitional CpG methylation between promoters and retroelements of tissue-specific genes during human mesenchymal cell differentiation. J Cell Biochem. 2007 Sep 1;102(1):224-39. doi: 10.1002/jcb.21291</ref> <ref>Gromolak S, Krawczenko A, Antończyk A, Buczak K, Kiełbowicz Z, Klimczak A. Biological Characteristics and Osteogenic Differentiation of Ovine Bone Marrow Derived Mesenchymal Stem Cells Stimulated with FGF-2 and BMP-2. Int J Mol Sci. 2020 Dec 20;21(24):9726. doi: 10.3390/ijms21249726</ref> <ref>Hung BP, Hutton DL, Kozielski KL, Bishop CJ, Naved B, Green JJ, Caplan AI, Gimble JM, Dorafshar AH, Grayson WL. Platelet-Derived Growth Factor BB Enhances Osteogenesis of Adipose-Derived But Not Bone Marrow-Derived Mesenchymal Stromal/Stem Cells. Stem Cells. 2015 Sep;33(9):2773-84. doi: 10.1002/stem.2060. Epub 2015 Jun 26</ref> <ref>Ambele MA, Dhanraj P, Giles R, Pepper MS. Adipogenesis: A Complex Interplay of Multiple Molecular Determinants and Pathways. Int J Mol Sci. 2020 Jun 16;21(12):4283. doi: 10.3390/ijms21124283</ref> <ref>Voskamp C, Koevoet WJLM, Somoza RA, Caplan AI, Lefebvre V, van Osch GJVM, Narcisi R. Enhanced Chondrogenic Capacity of Mesenchymal Stem Cells After TNFα Pre-treatment. Front Bioeng Biotechnol. 2020 Jun 30;8:658. doi: 10.3389/fbioe.2020.00658</ref> <ref>Sorrell JM, Somoza RA, Caplan AI. Human mesenchymal stem cells induced to differentiate as chondrocytes follow a biphasic pattern of extracellular matrix production. J Orthop Res. 2018 Jun;36(6):1757-1766. doi: 10.1002/jor.23820. Epub 2017 Dec 22</ref>.		It has been observed mesenchymal stem cells ([[MSC/en\|MSCs]]) have the ability to differentiate into many types of connective tissue, including: bone tissue ([[osteogeneza/en\|osteogenesis]]), cartilage ([[chondrogeneza/en\|chondrogenesis]]), adipose tissue ([[adipogeneza/en\|adipogenesis]]), skeletal muscle tissue (myogenesis), heart muscle (cardiomiogenesis), tendons, ligaments, as well as in in vitro tests for nerve tissue cells.<ref>Vazin T, Freed WJ. Human embryonic stem cells: derivation, culture, and differentiation: a review. Restor Neurol Neurosci. 2010;28(4):589-603. doi: 10.3233/RNN-2010-0543</ref> <ref>Kang MI, Kim HS, Jung YC, Kim YH, Hong SJ, Kim MK, Baek KH, Kim CC, Rhyu MG. Transitional CpG methylation between promoters and retroelements of tissue-specific genes during human mesenchymal cell differentiation. J Cell Biochem. 2007 Sep 1;102(1):224-39. doi: 10.1002/jcb.21291</ref> <ref>Gromolak S, Krawczenko A, Antończyk A, Buczak K, Kiełbowicz Z, Klimczak A. Biological Characteristics and Osteogenic Differentiation of Ovine Bone Marrow Derived Mesenchymal Stem Cells Stimulated with FGF-2 and BMP-2. Int J Mol Sci. 2020 Dec 20;21(24):9726. doi: 10.3390/ijms21249726</ref> <ref>Hung BP, Hutton DL, Kozielski KL, Bishop CJ, Naved B, Green JJ, Caplan AI, Gimble JM, Dorafshar AH, Grayson WL. Platelet-Derived Growth Factor BB Enhances Osteogenesis of Adipose-Derived But Not Bone Marrow-Derived Mesenchymal Stromal/Stem Cells. Stem Cells. 2015 Sep;33(9):2773-84. doi: 10.1002/stem.2060. Epub 2015 Jun 26</ref> <ref>Ambele MA, Dhanraj P, Giles R, Pepper MS. Adipogenesis: A Complex Interplay of Multiple Molecular Determinants and Pathways. Int J Mol Sci. 2020 Jun 16;21(12):4283. doi: 10.3390/ijms21124283</ref> <ref>Voskamp C, Koevoet WJLM, Somoza RA, Caplan AI, Lefebvre V, van Osch GJVM, Narcisi R. Enhanced Chondrogenic Capacity of Mesenchymal Stem Cells After TNFα Pre-treatment. Front Bioeng Biotechnol. 2020 Jun 30;8:658. doi: 10.3389/fbioe.2020.00658</ref> <ref>Sorrell JM, Somoza RA, Caplan AI. Human mesenchymal stem cells induced to differentiate as chondrocytes follow a biphasic pattern of extracellular matrix production. J Orthop Res. 2018 Jun;36(6):1757-1766. doi: 10.1002/jor.23820. Epub 2017 Dec 22</ref>.

	=~~Bibliografia~~=		=Bibliography=

Agnieszka Szyposzyńska: Utworzono nową stronę "It has been observed mesenchymal stem cells (MSCs) have the ability to differentiate into many types of connective tissue, including: bone tissue (osteogene..."

2021-04-27T13:10:11Z

Utworzono nową stronę "It has been observed mesenchymal stem cells (MSCs) have the ability to differentiate into many types of connective tissue, including: bone tissue (osteogene..."

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	~~W kontekście komórek~~ [[~~Mezenchymalne Komórki Macierzyste~~ \|~~MSC~~]] ~~zaobserwowano~~, ~~że komórki mają zdolność do różnicowania się w kierunku szeregu rodzajów tkanki łącznej m.in. w stronę tkanki kostnej~~ ([[~~Osteogeneza~~\|~~osteogeneza~~]]), ~~tkanki chrzęstnej~~ ([[~~Chondrogeneza~~\|~~chondrogeneza~~]]), ~~tkanki tłuszczowej~~ ([[~~Adipogeneza~~\|~~adipogeneza~~]]), ~~tkanki mięśnia szkieletowego~~ (~~miogeneza~~), ~~mięśnia sercowego~~ (~~kardiomiogeneza~~) ~~ścięgien~~, ~~więzadeł~~, ~~a także ''[[~~in ~~vitro\|~~in vitro~~]]'' w kierunku komórek tkanki nerwowej~~ <ref>Vazin T, Freed WJ. Human embryonic stem cells: derivation, culture, and differentiation: a review. Restor Neurol Neurosci. 2010;28(4):589-603. doi: 10.3233/RNN-2010-0543</ref> <ref>Kang MI, Kim HS, Jung YC, Kim YH, Hong SJ, Kim MK, Baek KH, Kim CC, Rhyu MG. Transitional CpG methylation between promoters and retroelements of tissue-specific genes during human mesenchymal cell differentiation. J Cell Biochem. 2007 Sep 1;102(1):224-39. doi: 10.1002/jcb.21291</ref> <ref>Gromolak S, Krawczenko A, Antończyk A, Buczak K, Kiełbowicz Z, Klimczak A. Biological Characteristics and Osteogenic Differentiation of Ovine Bone Marrow Derived Mesenchymal Stem Cells Stimulated with FGF-2 and BMP-2. Int J Mol Sci. 2020 Dec 20;21(24):9726. doi: 10.3390/ijms21249726</ref> <ref>Hung BP, Hutton DL, Kozielski KL, Bishop CJ, Naved B, Green JJ, Caplan AI, Gimble JM, Dorafshar AH, Grayson WL. Platelet-Derived Growth Factor BB Enhances Osteogenesis of Adipose-Derived But Not Bone Marrow-Derived Mesenchymal Stromal/Stem Cells. Stem Cells. 2015 Sep;33(9):2773-84. doi: 10.1002/stem.2060. Epub 2015 Jun 26</ref> <ref>Ambele MA, Dhanraj P, Giles R, Pepper MS. Adipogenesis: A Complex Interplay of Multiple Molecular Determinants and Pathways. Int J Mol Sci. 2020 Jun 16;21(12):4283. doi: 10.3390/ijms21124283</ref> <ref>Voskamp C, Koevoet WJLM, Somoza RA, Caplan AI, Lefebvre V, van Osch GJVM, Narcisi R. Enhanced Chondrogenic Capacity of Mesenchymal Stem Cells After TNFα Pre-treatment. Front Bioeng Biotechnol. 2020 Jun 30;8:658. doi: 10.3389/fbioe.2020.00658</ref> <ref>Sorrell JM, Somoza RA, Caplan AI. Human mesenchymal stem cells induced to differentiate as chondrocytes follow a biphasic pattern of extracellular matrix production. J Orthop Res. 2018 Jun;36(6):1757-1766. doi: 10.1002/jor.23820. Epub 2017 Dec 22</ref>.		It has been observed mesenchymal stem cells ([[MSC/en\|MSCs]]) have the ability to differentiate into many types of connective tissue, including: bone tissue ([[osteogeneza/en\|osteogenesis]]), cartilage ([[chondrogeneza/en\|chondrogenesis]]), adipose tissue ([[adipogeneza/en\|adipogenesis]]), skeletal muscle tissue (myogenesis), heart muscle (cardiomiogenesis), tendons, ligaments, as well as in in vitro tests for nerve tissue cells.<ref>Vazin T, Freed WJ. Human embryonic stem cells: derivation, culture, and differentiation: a review. Restor Neurol Neurosci. 2010;28(4):589-603. doi: 10.3233/RNN-2010-0543</ref> <ref>Kang MI, Kim HS, Jung YC, Kim YH, Hong SJ, Kim MK, Baek KH, Kim CC, Rhyu MG. Transitional CpG methylation between promoters and retroelements of tissue-specific genes during human mesenchymal cell differentiation. J Cell Biochem. 2007 Sep 1;102(1):224-39. doi: 10.1002/jcb.21291</ref> <ref>Gromolak S, Krawczenko A, Antończyk A, Buczak K, Kiełbowicz Z, Klimczak A. Biological Characteristics and Osteogenic Differentiation of Ovine Bone Marrow Derived Mesenchymal Stem Cells Stimulated with FGF-2 and BMP-2. Int J Mol Sci. 2020 Dec 20;21(24):9726. doi: 10.3390/ijms21249726</ref> <ref>Hung BP, Hutton DL, Kozielski KL, Bishop CJ, Naved B, Green JJ, Caplan AI, Gimble JM, Dorafshar AH, Grayson WL. Platelet-Derived Growth Factor BB Enhances Osteogenesis of Adipose-Derived But Not Bone Marrow-Derived Mesenchymal Stromal/Stem Cells. Stem Cells. 2015 Sep;33(9):2773-84. doi: 10.1002/stem.2060. Epub 2015 Jun 26</ref> <ref>Ambele MA, Dhanraj P, Giles R, Pepper MS. Adipogenesis: A Complex Interplay of Multiple Molecular Determinants and Pathways. Int J Mol Sci. 2020 Jun 16;21(12):4283. doi: 10.3390/ijms21124283</ref> <ref>Voskamp C, Koevoet WJLM, Somoza RA, Caplan AI, Lefebvre V, van Osch GJVM, Narcisi R. Enhanced Chondrogenic Capacity of Mesenchymal Stem Cells After TNFα Pre-treatment. Front Bioeng Biotechnol. 2020 Jun 30;8:658. doi: 10.3389/fbioe.2020.00658</ref> <ref>Sorrell JM, Somoza RA, Caplan AI. Human mesenchymal stem cells induced to differentiate as chondrocytes follow a biphasic pattern of extracellular matrix production. J Orthop Res. 2018 Jun;36(6):1757-1766. doi: 10.1002/jor.23820. Epub 2017 Dec 22</ref>.

	=Bibliografia=		=Bibliografia=